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Phenacetin CAS 62-44-2 Steroid source online / Kevin@ycgmp.com

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Active Pharmaceutical Ingredient Analgesic Antipyretic Drugs Phenacetin CAS 62-44-2 ACETOPHENETIDINE


Quick Details for Phenacetin 
Synonyms: 1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE 
CAS: 62-44-2 
MF: C10H13NO2 
MW: 179.22 
EINECS: 200-533-0 
Product Categories: Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs 
Melting point : 133-136 C(lit.)
Boiling point : 132 C / 4mmHg 
Storage temp. : 2-8C
Chemical Properties :  white crystalline powder 
Usage : Analgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens. 
Usage : glycosylation inhibitor .


Antipyretic analgesics 

The antipyretic and analgesic effects of phenacetin are similar to that of acetylsalicylic acid, which is mainly used as anti-inflammatory drugs with a slow and long-lasting effect. It is an effective drug on the treatment of headache, neuralgia, joint pain and fever. However, it has a weak effect on treating anti-rheumatic, anti-inflammatory. Overdose can cause methemoglobinemia, resulting in hypoxia. Long-term medication can damage the kidneys, and even cause papillary necrosis, thus it should be taken with caution. Owing to its side effect and the rapid development of other similar drugs, the drug has been discontinued alone and just used as an active pharmaceutical ingredient for compound preparation with other drugs. It is often combined with aspirin, caffeine, for making aspirin compound (0.162 g of non-phenacetin, 0.227 g of aspirin, and 0.035 g of caffeine) for the treatment of colds with a small toxicity. Further addition of a small amount of the chlorpheniramine can produce chlorpheniramine cold tablets which can be applied to the treatment of colds, headache, neuralgia, rheumatism and so on. 

Phenacetin itself has no antipyretic analgesic effect in the body; it takes effect only after metabolically breakdown into acetaminophen (paracetamol) that is paracetamol. Its decomposition also produces dapsone ether, which not only has no antipyretic analgesic effect but also causes the non-main factors phenacetin side effects.

China has begun produced phenacetin since 1954. First produce nitrobenzene from ether reaction from nitro chlorobenzene and ethanol, and then reduce nitrobenzene into phenetidine to have acetylation reaction with acetic acid, and obtain the final product. 


Phenacetin Uses 

1. Used for organic synthesis of raw materials and drug intermediates from acetaminophen ether. 

2. Antipyretic analgesics for the treatment of fever, headache, neuralgia.

3. Active pharmaceutical ingredient for Scientific Research.   
 
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Publish Date: Jul 12, 2017

Created by steroidsource

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